Asia Pacific Journal of Paediatrics Child and Health, Volume 7, Jan - Mar 2024
The relationship between preterm birth and the incidence of Multidrug Resistance Organisms (MDRO) in neonates
at Dr. Moewardi Hospital Surakarta
Fatimah Mayasyari1, Husnia Auliyatul Umma1, Sri Martuti1
1Department of Pediatric, Faculty of Medicine, Sebelas Maret University/Dr. Moewardi Hospital, Surakarta, Central Java, Indonesia
ABSTRACT
Background: Infection cases caused by Multi-drug Resistant Organisms (MDRO) have increased in the last few decades. Antimicrobial resistance is responsible for 30% of neonatal mortality worldwide. Preterm birth discovered as independent risk factor for MDRO in neonates associated with immature immune system. However, other studies suggested conversely.
Aims: To investigate the relationship between preterm birth and the incidence of MDRO in septic neonates at Dr. Moewardi Hospital Surakarta.
Methods: A retrospective analytic observational study with case control design conducted. The subjects were septic neonates proven by blood cultures hospitalized during January to December 2021 at Dr. Moewardi hospital Surakarta. This study used SPSS 25.0 with Chi Square bivariate analysis followed by multivariate logistic regression analysis.
Results: The subjects were 60 neonates, consisted of 30 MDRO and 30 non-MDRO neonates. There were 21 MDRO neonates (70%) born prematurely and 8 premature neonates (26,6%) in non-MDRO group. Chi square bivariate analysis found that low birth weight (OR=3.755, 95%CI=1.239–11.385, p=0.017), preterm birth (OR=6.417, 95%CI=2.084-19.755, p=0.001) and duration of antibiotic administration >7 days (OR=5.231, 95%CI=1.657-16.515, p=0.003) had p7 days (OR=3.939, 95%CI=1.106-14.032, p=0.034) had significant correlation with the incidence of MDRO in neonates.
Limitations: We had not been able to analyze medical personnel’s hand hygiene adherence because the data used is retrospective data.
Conclusion: Preterm birth was associated with the incidence of MDRO in neonates at Dr. Moewardi hospital Surakarta.
Keywords: MDRO, preterm birth, neonates, neonatal sepsis, antimicrobial resistance
Correspondence: Fatimah Mayasyari, E-mail: fatimahmayasyari@gmail.com